Proton Pump Inhibitors (PPIs) Diminish the Efficacy of Clopidogrel

In several observation studies, it has been suggested that a true pharmacologic interaction exists between clopidogrel (Plavix) and PPIs. Pharmacodynamic data suggest that competitive inhibition of CYP2C19 by PPIs decreases the availability of the active metabolite of clopidogrel and therefore diminishes its anti-platelet efficacy. This attenuation of anti-platelet effect of clopidogrel in conjunction with PPI has been supported in many platelet function studies and recent data has further shown that the decreased anti-platelet effect of clopidogrel translates into adverse cardiovascular outcomes.

More details:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262372/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491085/

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Proton Pump Inhibitors (PPIs) Diminish the Efficacy of Clopidogrel

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